Drug Discovery, Design and Development

Pharmacokinetics and Pharmacodynamics

Pharmacokinetics is a segment of pharmacology which involves the study of absorption, distribution, metabolism, and excretion of a drug. The principle Clinical pharmacokinetics applies to the safety and effective therapeutic management of drugs in an individual.

Pharmacodynamics is study of physiologic, biochemical, and molecular effects of drugs in the body. It is generally used to estimate the effect of drug in the systemic circulation. Only Pharmacodynaics can explain the most common mechanism of drug entering the systemic circulation after the first pass metabolism (Hepatic).