Vaccine Drug Delivery Systems

Vaccine is a material that induces resistance through immunologically mediated form to a disease but not necessary for infection. Vaccines are usually composed of attenuated or killed organisms or units or subunits of organisms or DNA encoding antigenic proteins of pathogens. Sub-unit vaccines though exceptionally specific and selective in reacting with antibodies often fail to point out such reactions in circumstances like changes in center of antibody, epitopic identification, and are poorly immunogenic. Antigens are delivered from oil-based adjuvants such as Freunds adjuvant lead to decrease in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants don't seem to be widely used. FDA approved adjuvants for human uses are aluminium phosphate and aluminium hydroxide in the form of alum. Hence, seek for potent and safer adjuvants resulted within the formulations of antigen into delivery systems that administer antigen in particulate form instead of solution form.

  • Live-attenuated vaccines
  • Inactivated vaccines
  • Subunit, recombinant, polysaccharide, and conjugate vaccines
  • Toxoid vaccines

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